Medical Markers of Candida

[bremen]

This thread contains references to attributes of Candida that seem to match the medical markers of KD. Not all of these are specifially about KD. These links are for another write-up that explains them at viewtopic.php?f=1&t=1830.

• “Superantigen-Like Effects of a Candida albicans Polypeptide.” http://www.pubmedcentral.nih.gov/articl ... id=2408734. From Yale in 2008.

• “Neutrophils Respond to Candida by Releasing Substances That Up-Regulate Endothelial Cell E-selectin Expression.” http://gateway.nlm.nih.gov/MeetingAbstr ... 45532.html

• “Migration of the fungal pathogen Candida albicans across endothelial monolayers.” http://www.pubmedcentral.nih.gov/articl ... tid=174492

• “Immunoglobulin G Responses to a Panel of Candida albicans Antigens as Accurate and Early Markers for the Presence of Systemic Candidiasis.” http://jcm.asm.org/cgi/content/full/46/5/1647

• “Effect of Candida albicans septicemia on the cardiovascular function of rabbits.” http://www.sciencedirect.com/science?_o ... a462718880, Candida need not be physically present in the heart. Quote: “In the heart and aorta, microscopic examination revealed no tissue invasion of C. albicans.”

• “Experimental pulmonary candidiasis in modified rabbits.” http://www.springerlink.com/content/g817366623l102r3/, Quote: “Furthermore, epithelioid granulomatous lesions at the late stage in the C. albicans-sensitized animals showed scattered epithelioid cells containing IgG as well as abundant IgG- and IgM-positive plasma cells.”

• “Mouse candidiasis. II. Host responses are T-cell dependent and regulated by genes in the major histocompatibility complex.” http://www.springerlink.com/content/v50g12322g977046/ Quote: “The rate of clearance of organisms from the spleen of congenic mice was determined by genes in the major histocompatibility complex, as was the magnitude of the inflammatory response in the popliteal lymph node after footpad immunization. These results formally demonstrate the involvement of T cells in host responses to primary candida infection.”
• “Increased Levels of Candida albicans Mannan-Specific T-Cell-Derived Antigen Binding Molecules in Patients with Invasive Candidiasis.” http://www.pubmedcentral.nih.gov/articl ... id=1459633

• “Killer-sensitive relationships in yeasts from natural habitats.” http://www.springerlink.com/content/j517lr317415580g/, Quote: “Killer strains release a killing substance which is lethal to sensitive strains. Neutral strains, which do not produce a killing substance, and a large majority of killers are immune to these substances.”

• Tolerance to staphylococcal enterotoxin B initiated Th1 cell differentiation in mice infected with Candida albicans. http://www.pubmedcentral.nih.gov/articl ... tid=303066. Is this something close to KD in the mice that experience increased mortality?

• TNF alpha:

• o “Intravenous injection of Candida-derived mannan results in elevated tumor necrosis factor alpha levels in serum.” http://www.pubmedcentral.nih.gov/articl ... tid=174413
  o “TNF- Is Necessary for Induction of Coronary Artery Inflammation and Aneurysm Formation in an Animal Model of Kawasaki Disease.” http://www.jimmunol.org/cgi/content/full/176/10/6294

• V beta:

• o “Candida albicans induces selective expansion of human T lymphocytes expressing the T-cell receptor variable region V beta 5.1.” http://www.ncbi.nlm.nih.gov/pubmed/8814546, Quote 1: “More importantly, analysis of the T cell infiltrate 48 h after intradermal injections with C. albicans also showed significant expression of V beta 5.1 in the infiltrates, along with the infiltration of V beta 8.1 + T cells.”, Quote 2 “…our present data raise the provocative possibility that one or more antigens in C. albicans can act as a superantigen, producing selective expansion of a population of T lymphocytes bearing a particular V beta specificity.”
  o “Selective expansion of T cells expressing T-cell receptor variable regions V beta 2 and V beta 8 in Kawasaki disease.” http://www.pubmedcentral.nih.gov/articl ... tid=525633,
  o “Tolerance to Staphylococcal Enterotoxin B Initiates Thl Cell Differentiation in Mice Infected with Candida albicans.” http://iai.asm.org/cgi/reprint/62/9/4047.pdf, Quote: “These data suggest that CD4+ V beta 8+ T cells play an important role in vivo in the initiation of a Th2 response to C. albicans and that suppression of their activity may alter the qualitative development of the T-cell response and the outcome of infection.”
  o “Importance of beta2-microglobulin in murine resistance to mucosal and systemic candidiasis .” http://www.pubmedcentral.nih.gov/articl ... tid=174493

• Interleukin:

• o “Incubation of human chorioamniotic membranes with Candida albicans induces differential synthesis and secretion of interleukin-1β, interleukin-6, prostaglandin E2, and 92 kDa type IV collagenase.” http://www3.interscience.wiley.com/jour ... 3/abstract
  o “The acute phase nature of interleukin 6: studies in Kawasaki disease and other febrile illnesses.” http://www.pubmedcentral.nih.gov/articl ... id=1541885

• TIMP, MMP2 and MMP9:

• o “Expression of Matrix Metalloproteinases during Experimental Candida albicans Keratitis.” http://www.iovs.org/cgi/content/abstract/50/2/737
  o “Systemic Arterial Expression of Matrix Metalloproteinases 2 and 9 in Acute Kawasaki Disease.” http://atvb.ahajournals.org/cgi/content ... t/23/4/576
  o “Elevated serum levels of matrix metalloproteinase-9 (MMP-9) in Kawasaki disease.” http://www.pubmedcentral.nih.gov/articl ... id=1906124

• SAPS

• o “The precursor of secreted aspartic proteinase Sapp1p from Candida parapsilosis can be activated both autocatalytically and by a membrane-bound processing proteinase.” http://www.reference-global.com/doi/abs ... C.2005.093
  o “Two aspartic proteinases secreted by the pathogenic yeast Candida parapsilosis differ in expression pattern and catalytic properties.” http://www.reference-global.com/doi/abs ... C.2009.034

• Fibronectin:

• o “Cloning and Analysis of a Candida albicans Gene That Affects Cell Surface Hydrophobicity.” http://jb.asm.org/cgi/content/full/183/ ... type=HWFIG
  o “Plasma fibronectin concentrations in mucocutaneous lymph node syndrome.” http://www.pubmedcentral.nih.gov/articl ... id=1777530

• “Thrombocytosis During Antifungal Therapy of Candidemia.” http://www.theannals.com/cgi/content/abstract/39/7/1238

• “Occurrence of atypical lymphocytes following intravenous injection of Candida albicans in mice.” http://www.springerlink.com/content/v72v20j876991516/

• normocytic anemia : “Epididymitis Caused by Candida glabrata: A novel infection in diabetic patients?” http://care.diabetesjournals.org/cgi/co ... 24/11/2003

• Increased ESR:

• o “Vertebral osteomyelitis due to Candida species : Case report and literature review .” http://cat.inist.fr/?aModele=afficheN&cpsidt=1104463
  o “Candida tropicalis spondylodiskitis in a patient with carcinoma of sigmoid colon: a case report.” http://www.casesjeditorial.com/content/1/1/66

• Increased c-reactive protein: “CANDIDA SEPTIC ARTHRITIS OF THE HIP IN A YOUNG PATIENT WITHOUT PREDISPOSING FACTORS.” http://www.jbjs.org.uk/cgi/reprint/85-B/5/734.pdf. There are many links – CRP is a measure of inflammation.

• Quorum sensing allows Candida to synchronize a systemic response:

• o “Yeast colonies synchronise their growth and development.” http://jcs.biologists.org/cgi/reprint/1 ... 923.pdf”
  o “Tyrosol is a quorum-sensing molecule in Candida albicans.” http://www.pnas.org/content/101/14/5048.full.
  o “In Kawasaki’s,”Greater than 95% of patients present with protracted fever, which has a remittent pattern of several temperature spikes each day (http://emedicine.medscape.com/article/1111884-overview )”

• The BCG vaccine and TB seem fungicidal and would induce greater responses in those with greater amounts of Candida and there is a significant relationship to TB noted in KD. I suspect this is not a killer-sensitive reaction:

• o “Usefulness of BCG reactivation in Incomplete Kawasaki Disease: A Case Series.” http://www.ispub.com/ostia/index.php?xm ... wasaki.xml
  o BCG as antifungal: “Activation of peritoneal macrophages by concanavalin A or Mycobacterium bovis BCG for fungicidal activity against Blastomyces dermatitidis and effect of specific antibody and complement.” http://www.pubmedcentral.nih.gov/articl ... tid=348022
  o BCG vaccine and then Candida: “The Role of BCG/PPD-Activated Macrophages in Resistance against Systemic Candidiasis in Mice.” http://www3.interscience.wiley.com/jour ... 4/abstract
  o Candida and then BCG: acute-KD from a systemic reaction? or 20% die-off and 50% inhibition as the BCG vaccination in the prior bullet?

• Orthophenylphenol, which has some controversy and implication in causing health problems, is a fungicide that we could inhale after a carpet cleaning. This could set off a systemic (sensitive or programmed cell death) die-off in those pre-disposed to, while they experience an enormous release of toxins:

• o “Microarray analysis of toxicogenomic effects of Ortho-phenylphenol in Staphylococcus aureus. “http://www.biomedcentral.com/1471-2164/9/411
  o “USE OF ORTHO-PHENYLPHENOL AND/OR DERIVATIVES THEREOF FOR INHIBITING THE ASEXUAL REPRODUCTION OF FUNGI” http://www.wipo.int/pctdb/en/wo.jsp?wo=2006015725

• Biotin seems to de-colonize Candida in experiments and naturopathic treatments:

• o Mold-help website: http://www.mold-help.org/content/view/411/
  o “The Role of Biotin in the Treatment of Candida.” http://www.nativeremedies.com/articles/ ... ndida.html
  o “Mycelial development and chemical alteration of Candida albicans from biotin insufficiency.” http://www.informaworld.com/smpp/conten ... 957~db=all

• Melatonin:

• o “Effects of melatonin on Candida sepsis in an experimental rat model.” http://cat.inist.fr/?aModele=afficheN&cpsidt=18938898
  o “The Irving Family and KD.” http://www.kdcanada.ca/e107_plugins/for ... ic.php?293

• Season correlation to mold/fungi life cycle: there was an article by Wisconsin university I had linked which has since disappeared. The mold/fungi life cycle closely matches the seasonal outbreaks noted in KD. Not a strong argument, but interesting food for thought. I have an email out and hopefully can provide a link soon.

[sydneli]

Hmm-that's a lot of information, but timely. My husband is being treated for chronic Lyme disease, and has been developing oral thrush due to the antibiotics he is on. My son Jordan, who had KD 2 years ago this week and also has giant CAAs, complained of his tongue hurting a few weeks ago. It's also oral thrush, and we can't get rid of it. I'm going to have to try to dissect some of this info...

[walk]

Hmm-that's a lot of information, but timely. My husband is being treated for chronic Lyme disease, and has been developing oral thrush due to the antibiotics he is on. My son Jordan, who had KD 2 years ago this week and also has giant CAAs, complained of his tongue hurting a few weeks ago. It's also oral thrush, and we can't get rid of it. I'm going to have to try to dissect some of this info...

What kind of treatment methods did you try for attempting to get rid of the oral thrush?

[bremen]

Hi, I put a lot of research and effort into this thread 2 years ago along with the one it references here: viewtopic.php?f=1&t=1830 so I wish to bump it.

Millions of dollars spent doing the same things that were done a decade ago and republishing the same work. The field of medicine is stagnant and caught in a paradigm that has beaten the very simple idea of a single infection illness to death. Your bodies are loaded with organisms. Why do we suspect that complex illnesses are defined by the same mechanism that give you the flu with some genetic mysticism thrown in? It is my hope that somebody doing doctoral research finds this thread and sees that the interaction between 'infections' is most definitely an area that needs studied. The idea is that your body has an 'infection' though not really an infection since it is something benign like the superantigen Candida. You have grown too much of it (genetics) and it has probably entered the blood stream because of genetic disposition. You introduce a trigger such as what the KD parents report - vaccine, carpet cleaner, swamp bugs, etc. The trigger causes the 'killer sensitivity reaction' or 'programmed cell death'. The massive die-off of a rampant (benign) infection in your body causes what looks like sepsis, which (I propose) is what modern medicine calls KD. In natural medicine this would be called a 'herxheimer reaction' but in modern medicine this label is limited to a definition somebody created. The area the infection is most present (or releases toxins to via the blood) is where you are seeing the varied outcomes - in my case, the liver (which is fine post-KD). Whether you get the KD trigger or not, you get some of the other stuff natural medicine attributes to a 'benign' base infection - ADHD, allergy, sinus, arthritis, fibromyalgia, etc. Look at your genetic lines. I bet you can easily find the 'other stuff' if somebody has had KD in your bloodlines.

The animal models of KD support this type of scenario and I have found no data to refute the idea of 'concomitant' infection. In fact, not a lot of research has been performed on this concept which is not very complicated - 2 competing infections, 1 of which normally lives in the body. The 'benign' infections of-self that medicine does not recognize is what naturopathy/homeopathy treats. While I may not be 100% accurate in my terms, understanding and writing, I am 100% certain that this is where the field of autoimmunity needs to be looking. This is my opinion from reading tons of articles and not a fact. It needs researched, desperately, and as I stated, I hope that a proper medical researcher takes this up.

I have written why I believe this and collected a hideous amount of medical experiments/research here: http://kawasakitheory.webs.com/

~J

[liquidambar]

Mark Blaxill and Dan Olmstead have written a lot about metals thrown into the mix of pathogens maybe be the culprit of all of our ills. With metals - pathogens more easily enter the perphrial nervous system, brain, nerves, the lining of our blood vessels.

Mercury - they look at how it was used to treat syphlis- without being treated with mercury - the patients did not become insane.
Arsenic - Used for a while to treat crops of apples and blueberries - they argue is the reason for the emergence of paralizing polio.
Chromium 6- Effects the T cells, well the whole immunity thing, as in the movie "Erin Brockovich ".
Aluminium: I do remember back in the 70s if was a well known that alziheimer patients were told that alumium was in their brains (that is what they said)
60 minutes did a segment - on an old couple, and they were trying to eliminate all alumium from their diets. the old lady had thrown out all of her alumium cookware.

Organo choloride pesticides like DDT - also acted a lot like the metal and allow pathogens to get into places they ordinarly could not get.

My mother-in-law with her thyroid problems at a young age-- as well as all 3 of her sisters with thyroid problems - She- later in life had all kinds of immune problems from asthma to demenita - the beginning of her problems she claimed was from a flu bug. She had a severe headache and afterwards she could not lift her arms to brush her hair-- she died of congential heart failure - "stiff heart".
She also remembers having the windows open the day before she became ill, and they were spraying the orange groves out in California.

[bremen]

LA, I had begun researching the heavy metal aspect. From memory, I had found that a 'benign' infection like Candida will absorb lots of mercury/thimerosal according to scientific studies. It will also transform thimerosal into mercury. Under what I have written, if you kill off a huge amount of this 'benign' infection of-self using signals from another bug (killer sensitivity or programmed cell death as the mechanisms), then all of the heavy metals they have absorbed are released as well - all at once. This was the next step in my research when I stopped. I do believe that the culmination is a huge toxic release from the bugs themselves dying (Herxheimer reaction) coupled with a release of heavy metals that were absorbed in the bugs that died. Why does the skin peel off the fingers and toes in KD? Is it high fever, sepsis or something more along the lines of mercury poisoning from a release of all of the crap absorbed into the 'benign' infection of-self? I don't have medical references readily available but they should not be difficult to find for anybody reading this.

Look at this:
http://www.autismweb.com/forum/viewtopic.php?t=7726

[liquidambar]

Hi Breman;

There is something about the yeast infections, that seem to be really abnormal. That is interesting about yeast absorbing mercury. Very interesting that all the parents of the autistic kids are discussing skin peeling on the website you gave.

What I do know is Organic mercury the safe versions are called; ethyl and methyl mercury.
Ethyl means it has two carbon atoms (same stuff we are made of) attached to it. Methyl means a carbon atom with three hydrogens attached to it and it is attached to a atom of mercury. This makes mercury organic and that means it is more easily absorbed than just plain mercury that is inorganic into the body.

Ethyl mercury and methyl mercury was found not to be as deadly as dimethyl mercury ( has two groups of atoms and each group is a carbon atom with three hydrogens) but anyway dimethyl mercury is a compound that killed a famous chemist working with it - went right through her rubber gloves apparently. But ethyl and methyl proved to be safer and they started using them in fungicides in the lumber industry,in seed disinfectants, used as a lawn chemical, and used in medicine - vaccines.

As a child I was always under foot when it came to planting the garden. I especially loved to bother my grandmother, I was her favorite grandchild because like her I loved plants, and I am still a big gardener. One spring when I was very small, I poured out the bag of seed corn into my hand, and to my surprise they were a really pretty pink. I remember asking my grandmother why they were pink, and she said she did not know, but asked my grandfather who had just handed me the bag. He said it was a poison to kill all the stuff that kept the corn from growing, as he headed out for his work. Grandma was more cautious than my grandfather and told me to drop those seeds right now. I was probably four at the time (not in school yet), and I probably dropped them and then licked the pink stuff off of my hands, no hand washing went on much, esp in the middle of planting a garden.

Maybe I set my kids up for later on with more mercury in vaccines?
Maybe I set myself up because twice - once in my 20s and again in my late 30's I received a tetanus shot that I found out later was really a DPT shot - and right after both I had trouble with yeast infections?

At age 45 when my thyroid started really going out - I had a constant yeast infection (I am talking years here). Finally at one point a very good doctor gave me a prescription with lots a refills that lasted three months to kill out the yeast infection-- and it worked for a couple of years. Then it started coming back but always in the fall of the year - around Oct . I could get rid of it, if I took just a little extra amount of thyroid medicine, but soon it required a bit more, and a bit more - and I was then taking a lot of thyroid medicine to just keep it in check. I felt I should not be messing with a prescription medicine so. I finally took vitamin D and that seemed to do the trick.

The last time I had trouble was two weeks into the Atkins diet, and it was pretty bad - every muscle in my body hurt - even the bottom of my feet when I stepped on the ground. But after that - no more problems ever! Not even in the fall even if I forget to take my vitamin D.

I know this is all personal, my own personal outlook - experience, but it seems that is all that I have to go on.

And skin peeling off - Skin peeling off of fingers and toes was common for kids that had scarlett fever and rhematic fever. The thought was it was caused by a high fever, but there were lots of high fevers from other things like typhoid were the hair would fall out, but no mention of peeling . It would be interesting to know what is causing the peeling esp for those kids from the website you gave me. I wonder if they might be suffering from atypical Kawasakis or incomplete Kawasakis and they do not recognize it for what it is.

[liquidambar]

And skin peeling off - Skin peeling off of fingers and toes was common for kids that had scarlett fever and rhematic fever. The thought was it was caused by a high fever, but there were lots of high fevers from other things like typhoid were the hair would fall out, but no mention of peeling . It would be interesting to know what is causing the peeling esp for those kids from the website you gave me. I wonder if they might be suffering from atypical Kawasakis or incomplete Kawasakis and they do not recognize it for what it is.