Another genetic link to KD

Technical & specific medical articles covering many areas Kawasaki-related
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Momcat
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Another genetic link to KD

Post by Momcat » Sun Jan 16, 2011 10:15 am


liquidambar
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Re: Another genetic link to KD

Post by liquidambar » Tue Oct 11, 2011 9:02 am

I wish I had a penny for all the times I have read similiar reports.
At the end of this report in the summary they state "These results implicate a locus" still not sure are they?

Momcat
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Re: Another genetic link to KD

Post by Momcat » Thu Oct 13, 2011 2:23 am

Wow, breaking down genetic codes is not easy and then defining which seem to be implicated in KD seems a whole lot better than some theories where people just kind of throw sticks and stones at a certain events (without evidence or rational) is better?? Sorry, add me on to the list of those that gets more bang for the buck out of scientific unbiased data vs. a wish and a prayer and a "feeling" of someone bound and determined to be heard.....

liquidambar
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Re: Another genetic link to KD

Post by liquidambar » Thu Oct 13, 2011 10:05 am

Here is another stick.
Money has been supporting non-productive gene researchers, a good living by the way, for a very long time. How long do we give them? A year, a decade, a quarter of a century, a life time - to tell us we have defective children?

Then after we are all dead - oh that money was wasted because it was something in the environment all along.

I resent wasted money, since I myself have always had little of it.

Momcat
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Re: Another genetic link to KD

Post by Momcat » Sat Oct 22, 2011 11:03 pm

I still shake my head at someone who doesn't understand how many CURES have been found recently because of the study of genetics. Did you even know that the DNA codes were just broken a few years ago? Gene research is in its INFANCY. WASTED money? I dare you to say that to just ONE parent whose child has been saved from genetic research that has lived after cancer or another disease would have killed them. In fact, my daughter lost a close friend at 7 years old to Ewings Sarcoma, it was not long after that we found they have FOUND the cure for it for kids that got the experimental doses and it COULD have been put out for doctors to use and it CURED the kids. However, it was TOO COSTLY TO MAKE and drug manufacturers could not turn the profit they wanted and the drug was never funded. Somewhere along the line you have to get off your illogical thinking that some higher powers are controlling research. This is tough science, and to think that most likely it took extraction and study after study and replication of who knows what and some engineering or whatever to FINALLY come up with the cure to STOP cells from replicating to cure a cancer and THEN to be told, SORRY it's TOO EXPENSIVE to reproduce? Do you even realize that most cancers are thought to be some sort of viral/immune system response/etc.....that it could be a host of different things that all collide together to cause leukemia,etc? Just like KD, they are UNRAVELING answers---ever so slowly.

liquidambar
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Re: Another genetic link to KD

Post by liquidambar » Sun Oct 23, 2011 10:39 am

I dare, I dare I double dare you??????
Sorry couldn't help it, but it came off as a rather challenging statement when obviously - I did dare!

Environmental science is yet another science toooooo..... but we forget because we Americans like new stuff.

Breaking the human genome is all bright, new and shiny; since they got the brillant idea to give a part of the human genome to thousands of labs world wide to break it down really fast --- They started it in 1990 and finished in 2003.

However: Most of the genetic diseases were teased out of the genome long before the human genome project was even thought up. I know this because I took genetics in college way back in 1977, and the text book was full of genetic diseases.

If a disease is not stable in the population, if there is an increase or decrease or ups and downs spkies --- it is environmental

That is ususally learned by all the college students in Environmental Health 101, but that don't keep some researcher needing a job to abuse that piece of knowledge.

Nancy
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Re: Another genetic link to KD

Post by Nancy » Sun Oct 23, 2011 5:48 pm

Momcat,

Thank you :)

nancy

Momcat
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Re: Another genetic link to KD

Post by Momcat » Sun Oct 23, 2011 7:47 pm

liquidambar wrote:However: Most of the genetic diseases were teased out of the genome long before the human genome project was even thought up. I know this because I took genetics in college way back in 1977, and the text book was full of genetic diseases.
Say what???
I have never heard anyone say that Kawasaki Disease is a genetic disease, have you? Most arguments say there is a TRIGGER and because of the way SOME people are put together (which is your own genetic code) then you will respond differently--possibly to some wort of invader- chemical, viral, bacterial.....whatever! It isn't like KD is there all the time from birth from what I've seen in research. And certainly it doesn't seem to stick around after the acute stage, so it isn't like we are born with it, or that after we get it we still have it forever.
I am so happy you are so sure of yourself. I just kind of wonder why no one else really agrees with your.....logic?? I've never heard of anyone so anti-research. Yes, the codes were broken down--that was the BEGINNING. Now, how do the bodies systems work? How do chemicals make these certain systems respond? Why is it that people who get KD are also immune to AIDS (ever heard that one?) Why does it have a higher possibility in some families? What parts of the millions of places in the DNA does the problem exist that makes someone succeptible, is it timing? Is it when one system is under attack from something else? There are zillions of unanswered questions with how each system in the body operates and each of us is unique. The greatest feat of all would be to engineer something for each individual to help with the quality of life. If we can help scientists find the answer for KD that would break the chain of events that causes KD, wow....what an honor that would be to help others. It is all bright new and shiny? It is miraculous.
So glad you read your genetics handbook in 1977. That makes me feel secure with your knowledge of genetic research in 2011. Let me guess, did you graduate with a BS in Genetics? I've never said there may not be an environmental trigger. I don't think anyone has. So, it just looks like your theory is that we are all the same inside genetically, that there are some screw ups in a few parts of the DNA that make up for some genetic diseases that can be passed on and that everything else wrong with people is because something came in from the environment ? So KD is just floating around out there in the air and anyone can get it? Wow. No wait, you say it is caused by vaccinations. How do people get it that have never been vaccinated? If KD is floating around out there, then there could be a big KD outbreak someday?
The dare came from telling a parent that the research done to provide her child with a cure with worthless. I can find some of those people if you do want that dare and it sounds like you do.
Environmental science is a huge - very big in this age. Probably more researchers in that field now than ever before. Heck, I hold two science degrees from Oregon Institute of Technology ( as long as we are going to brag about what we got out of college ) and OIT has a fantastic Environmental program. Seems odd to pit one science against another -- they usually have to work together to make progress. Tons of genetic studies have to be done with environmental research.
I don't think you get it yet. No one has said that KD is strictly genetic. What they have said is HEY LOOK, the people who GET KD have this in common on this tiny sequence of their DNA..... so ya, bring on a trigger, or two or more, in a kid that is succeptible to some immune system not functioning right (because of a certain twist or two or three in the codes), plus a little of this and that and LOOKOUT you have KD coming on light, medium or strong..... it's a THEORY.

liquidambar
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Re: Another genetic link to KD

Post by liquidambar » Mon Oct 24, 2011 8:39 am

Momcat you broad brush what I am saying.
You also are too trusting a human being when it comes to authority figures, you need to work on that. Trust but verify like everythig else in your life.

As far as this study and the 1000's like it --- it is like these researchers are finding the door wide open, the lock and key gone, stuff all stolen and for some reason "the scientist" obsesses over trying to find the lock and key; but not the person that actually put the key in, turned the lock, and stole the stuff, and certainly not worried about getting the stolen stuff back or replacing it. In other words these studies are usless.

AIDS - OH YES: I read the archives of what you said - from a Kawasakis meeting you and Paige went to. It sounded like a fun trip that will in future you and Piage can remember with fondness. If I remember right it went someting like this: they said it is the people who could not get AIDS had a tendency to get Kawaskis. I must admit I did think on this one a lot. I was well aware that there are people that do not get AIDS, and are the same people who are descendants of those that survived the Black Death in Europe hundreds of years ago.

Read this Please:
http://gateway.nlm.nih.gov/MeetingAbstr ... 99258.html

You will find in this article that HIV patients some times well ---- at the end of the study it says: "CONCLUSIONS: Patients with severe HIV disease may be at risk for developing Kawasaki disease."

or this one;
http://cid.oxfordjournals.org/content/36/1/105.full

The above link title is: "Recurrent Kawasaki Disease—like Syndrome in a Patient with Acquired Immunodeficiency Syndrome" and is very gruesome - it even has pictures. Take a look because those eyes and those hands sure look like Kawasakis in the poor AID patient.


But since you mentioned AIDS - what did it take for the GAY community that was dying like flies to get some help from the CDC and scientists?
If you remember , they were very vocal and made the scientists, federal government put federal funds toward research that would actually lead some where. Research that counts! Scientists, and esp federal agences tend to dilly dally - that is why we need to stay on their case.

Which gets us back to the fact that Kawasakis disease is not stable in the population. Over the years it spikes, but on the whole it is on a steady increase.

As a matter of fact ever disease that is listed as immune based is increasing. This is a fact - CDC useless as it has been - has said this , and they should know since it is their main job to gather statistics on all diseases.

Momcat
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Re: Another genetic link to KD

Post by Momcat » Fri Oct 28, 2011 1:08 am

No, as usual you don't remember well....and also we do not go to KD Symposiums and remember the times fondly. YOU are not an authority figure. Get over yourself LA and PLEASE quit trying to be logical with me as I absolutely do not take much of what you say as logical.
No, I did not say that people with AIDS are likely to get KD. Say what? The researchers in Seattle said they found that the same people who are IMMUNE to AIDS have something in common genetically with kids that get KD. Wow. But please don't worry about it. That would be something to do with genetics and we know you don't think there are any genetic issues associated with KD. Personally I think that the only reason people would ever have an issues with this (and I only know ONE) would be they might feel like there is NOTHING "wrong" genetically in their family so the child "caught" KD.....it certainly couldn't be that in the zillions of combinations of genetic code something was just a little different. Say like saying redheads burn more......but that would be BAD??? No, I forgot, we are all the same to you. Variation doesn't mean that something is wrong.......it just means it is a variation.
What part about this is something YOU NEVER UNDERSTAND. Take a kid , named Sammy that has a code in his immune system that leaves him succeptible to something in the environment....chemical, viral...whatever....(used with tons of examples of other things besides KD too).......there he is just being a kid and doing what kids do. Now, something in the environment is spiked.....who knows......KD happens more in winter, so lets say it is a virus that only comes out in a wet winter or something.......it is floating around out there and all the kids are sniffing it and nothing happens to 99.99% of them, but then WHAMMO, it finally hits Sammys nostrils and gets into his system and HIS system sees the virus as something it is not and goes HAYWIRE. It starts attacking his coronary arteries of all things.....guess what??? Environment TRIGGERS this one kid who has a different code regarding this particular small tiny area in one teeny tiny part of his immune system and either something doesn't STOP the body from attacking itself........or whatever and Sammy's own body is has gone auto - immune on him and started destroying its arterial linings. SO the doctors finally diagnose Sammy-rather late most likely....and start pumping IVIG into him, because it is full of stuff that we do not understand regarding the immune system and whatever is in there SHUTS DOWN the response that was on hyperdrive in Sammys body destroying his arteries. Guess what??? THAT MUCH THEY HAVE FIGURED OUT! So what is your issues about genetics and a trigger-probably environmental. WHY are you so weirded out that science sees it this way???

liquidambar
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Re: Another genetic link to KD

Post by liquidambar » Fri Oct 28, 2011 5:01 pm

Momcat;
I said:
"they said it is the people who could not get AIDS had a tendency to get Kawaskis. "
I said:
"I was well aware that there are people that do not get AIDS, and are the same people who are descendants of those that survived the Black Death in Europe hundreds of years ago."

You said: "No, I did not say that people with AIDS are likely to get KD. Say what? The researchers in Seattle said they found that the same people who are IMMUNE to AIDS have something in common genetically with kids that get KD. Wow"

You said: "Why is it that people who get KD are also immune to AIDS (ever heard that one?)"


We agree on what you said!

But it is not true, not when you can find AID patients or HIV patients who also have Kawasakis.

Too bad you can't stop slinging slurrs around long enough to read and understand my posts. But that it okay, I need to get my blood boiling now and then - Thank You Momcat.

Mom Cat - think about this question, take your time to look around for the answer. I challenge you to find this answer.
Name one genetic disease with an environmental trigger, and that is not stable in the population but is increasing?

Deniz Yeter
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Re: Another genetic link to KD

Post by Deniz Yeter » Sun Nov 20, 2011 7:22 pm

To explain this in laymen's terms...

The PELI1 gene is involved in negatively regulates T cells and other immune cells which result in it preventing autoimmunity, for example Kawasaki syndrome.

A dysfunction with this gene would result in an inability to negatively regulate T cells and other immune cells properly, leading to an increased susceptibility of autoimmunity or other immune dysfunction. Since Kawasaki syndrome is an autoimmune vasculitis in which the immune cells infiltrate and attack the blood vessels, resulting in widespread inflammation, dysfunction of PELI1 would increase the risk for Kawasaki's.

Also, T cells are well known to be intimately involved in the immune cascade resulting in the autoimmune reaction seen in Kawasaki's.


Basically, the T cells and immune system go crazy because the parents aren't home enforcing the rules and keeping them in line!

ESC1222
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Re: Another genetic link to KD

Post by ESC1222 » Mon Mar 18, 2013 7:21 pm

I realize this is an OLD post, but I have to chime in.
Isn't saying that people who get Kawasaki's are immune to AIDS different than people who have AIDS COULD get Kawasaki's?
That may not make sense, but in reading through the thread, it seems like we are talking about AIDS coming first in one sentence and Kawasaki's coming first in the other. I would think both could be true.

For what it's worth, my son was diagnosed with KD in December at 19 months of age. I totally believe that he was exposed to something environmentally (I have no idea what and probably never will-a virus or whatever) that caused his KD due to his genetic structure.

Angie
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Re: Another genetic link to KD

Post by Angie » Thu May 23, 2013 7:27 pm

Thanks for sharing :)

Not sure about everyone else on this thread but my child had KD and I'm just thankful there was IVIG available and someone knew what to do for her when she was 3 years old. I've been a member here since 2005 and although I don't post very often, I've never seen people argue like you all have in this thread over any topic. There really isn't a point. I, like all of you, would love to know what causes KD. In our situation, we were out of town when our little girl got sick up north and in the dead of winter. But we visited several places that most likely had been cleaned recently with cleaners (our vacation house, ski resort child care center, rental car, rental car carseat she rode in, airplane) so there is no way we would ever be able to figure it out and it drove me crazy for a little while until I just realized I was thankful there was a cure for it and that she turned out okay and back to her healthy self in no time.

Let's just all be thankful that our family member, friend or loved one is okay now in the present time (providing that they are) and that there is treatment available.
~*~Mommy to 3 wonderful children~*~ Member here since 2005
Daughter successfully treated for KD in December of 2005 at the age of 3.
Now a happy, vibrant, active 12 year old~*~

Nancy
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Re: Another genetic link to KD

Post by Nancy » Mon Aug 15, 2016 12:02 pm

hi

Could you kindly site the source of what appears to be an abstract from a medical journal ?

thanks
Nancy

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